Objectives: We conducted a systematic analysis of the notifiable rickettsial diseases in humans in China during 1950-2022.Methods: We utilized descriptive statistics to analyze the epidemiological characteristics, clinical manifestations, and diagnostic characteristics of typhus group rickettsiosis (TGR) and scrub typhus (ST) cases.Results: Since t
Moonlighting functional centers within proteins can provide them with hitherto unrecognized functions.Here we review how hidden moonlighting functional centers which we define as binding sites that have catalytic activity or regulate protein function in a novel manner, can be identified using targeted bioinformatic searches.Functional motifs used i
Achalasia is an esophageal motility disorder that is commonly misdiagnosed initially as gastroesophageal reflux disease.Patients with achalasia often complain of dysphagia with solids and liquids but may focus baja mini bike seat on regurgitation as the primary symptom, leading to initial misdiagnosis.Diagnostic tests for achalasia include esophage
The European Medical Agency (EMA) has issued a draft guideline on the quality and equivalence of topical products.The equivalence for complex semisolid formulations involves several steps: the same quantitative content, the same microstructure, the same release, and permeation profile.In this paper, several batches of a low strength topical product